Name | N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide |
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Synonyms |
Pilzicainide
Pilsicainide HCl Pilsicainida [INN-Spanish] n-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide Pilsicainidum [INN-Latin] Pilsicainide Pilsicainide [INN] |
Description | Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent[1][2]. |
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Related Catalog | |
In Vitro | Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1]. |
In Vivo | Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current[1]. Animal Model: Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment[1] Dosage: 2 mg/kg Administration: Bolus injection into right external carotid vein within 2 minutes, once Result: Elongated the QT interval at 15 and 60 minutes after administration. Shortened P wave and QRS complex durations. Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations. |
Density | 1.11 g/cm3 |
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Boiling Point | 416.9ºC at 760 mmHg |
Molecular Formula | C17H24N2O |
Molecular Weight | 272.38500 |
Exact Mass | 272.18900 |
PSA | 32.34000 |
LogP | 3.27130 |
Index of Refraction | 1.581 |
Storage condition | room temp |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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~% 88069-67-4 |
Literature: Journal of Medicinal Chemistry, , vol. 28, # 6 p. 714 - 717 |
~% 88069-67-4 |
Literature: Journal of Medicinal Chemistry, , vol. 28, # 6 p. 714 - 717 |
~% 88069-67-4 |
Literature: Journal of Medicinal Chemistry, , vol. 28, # 6 p. 714 - 717 |
~% 88069-67-4 |
Literature: Journal of Medicinal Chemistry, , vol. 28, # 6 p. 714 - 717 |
Precursor 5 | |
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DownStream 0 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |