27415-25-4

27415-25-4 structure

Name: 8-iso Prostaglandin E2
Chemical Name: 8-iso Prostaglandin E2
CAS Number: 27415-25-4
Molecular Formula: C₂₀H₃₂O₅
Molecular Weight: 352.465
Create Date: 2016-04-12 00:16:40
Modify Date: 2025-08-26 17:12:07
8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway[1][2].

Name	8-iso Prostaglandin E2
Synonyms	l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid (5E,13E)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid 5-Heptenoic acid, 7-[3-hydroxy-2- (3-hydroxy-1-octenyl)-5-oxocyclopentyl]- (5Z,8β,11α,12ξ,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- 7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid (5E)-7-{3-Hydroxy-2-[(1E)-3-hydroxy-1-octen-1-yl]-5-oxocyclopentyl}-5-heptenoic acid Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,8β,11α,12ξ,13E,15S)- 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-, l- Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5E,13E)- 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid

Description	8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
References	[1]. Wilson SJ, et al. Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling. Biochem Biophys Res Commun. 2007;352(2):397-403. [2]. Tintut Y, et al. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J Biol Chem. 2002;277(16):14221-14226.