143492-38-0

143492-38-0 structure

Name: D- erythro MAPP
Chemical Name: N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide
CAS Number: 143492-38-0
Molecular Formula: C₂₃H₃₉NO₂
Molecular Weight: 361.561
Catalog: Research Areas Cancer
Create Date: 2017-03-12 20:05:34
Modify Date: 2024-01-10 08:54:33
D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].

Name	N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide
Synonyms	N-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]tetradecanamide Tetradecanamide, N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]- MAPP,D-erythro N-[(1S,2R)-1-Hydroxy-1-phenyl-2-propanyl]tetradecanamide D-erythro-MAPP

Description	D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	D-erythro-MAPP (D-e-MAPP) reduces the viability of MCF-7 cells in a dose-dependent manner with IC50 value of 4.4 μM, and 15.6 μM, respectively[1]. D-erythro-MAPP (D-e-MAPP) induces G0/G1 arrest in cell cycle progression resulting in growth suppression[2]. Cell Viability Assay[1] Cell Line: Human breast cancer MCF-7 cells. Concentration: 24 h. Incubation Time: 3.13-100 μM. Result: Inhibited cell viability.
References	[1]. Hüseyin İzgördü, et al. Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor. Cytotechnology. 2020 Dec;72(6):907-919. [2]. A Bielawska, et al. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24;271(21):12646-54.