Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: HEMANTHAMINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

466-75-1

466-75-1 structure

Name: Haemanthamine
Chemical Name: Haemanthamin
CAS Number: 466-75-1
Molecular Formula: C₁₇H₁₉NO₄
Molecular Weight: 301.33700
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2017-12-16 17:30:58
Modify Date: 2024-01-09 20:53:12
Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

Name	Haemanthamin
Synonyms	Epihaemanthamin Haemanthanin Natalensin 3-Epicrinamine Natalensine

Description	Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Cancer Research Areas >> Infection Research Areas >> Neurological Disease
In Vitro	Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability[2]. Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation[2]. Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress[1]. Cell Viability Assay[2] Cell Line: A2780 ovarian cancer cells Concentration: 1 µM, 10 µM, 50 µM, 100 µM Incubation Time: 24 hours, 48 hours Result: Showed a time- and dose-dependent decrease in cell viability. Cell Proliferation Assay[2] Cell Line: A2780 ovarian cancer cells Concentration: 10 µM Incubation Time: 24 hours, 48 hours, 72 hours Result: Led to a significant inhibition of A2780 cell proliferation.
In Vivo	A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration[1].
References	[1]. Pellegrino S, et al. The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure. 2018 Mar 6;26(3):416-425.e4. [2]. Seifrtová M, et al. Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine. 2017 Nov 15;35:1-10.

Density	1.42g/cm3
Boiling Point	467.5ºC at 760 mmHg
Molecular Formula	C₁₇H₁₉NO₄
Molecular Weight	301.33700
Flash Point	236.5ºC
Exact Mass	301.13100
PSA	51.16000
LogP	1.12460
Vapour Pressure	1.53E-09mmHg at 25°C
Index of Refraction	1.679
Storage condition	-20°C

Precursor 0
DownStream 1
224-11-3

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