143443-90-7

143443-90-7 structure

Name: Ifetroban
Chemical Name: Ifetroban
CAS Number: 143443-90-7
Molecular Formula: C₂₅H₃₂N₂O₅
Molecular Weight: 440.53200
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2018-06-22 16:19:07
Modify Date: 2024-01-13 22:09:05
Ifetroban is a long-acting thromboxane A2 receptor antagonist, with antiplatelet activity[1].

Name	Ifetroban

Description	Ifetroban is a long-acting thromboxane A2 receptor antagonist, with antiplatelet activity[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Target	Thromboxane A2 receptor[1]
In Vitro	Ifetroban is a long-acting thromboxane/prostaglandin endoperoxide receptor antagonist, with antiplatelet activity[1].
In Vivo	Ifetroban (20, 40 mg/kg/day, i.p.) shows no effect on the blood pressure in stroke-prone spontaneously hypertensive rats[1]. Ifetroban (BMS 180,291; 1 and 3 mg/kg, p.o.) inhibits aggregation and antagonizes TP-receptor in monekys. Ifetroban (3 mg/kg, i.v.) causes only marginal and transient hemodynamic effects in anesthetized African green monkeys[2].
References	[1]. Johnson RA, et al. Effect of ifetroban, a thromboxane A2 receptor antagonist, in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1996 Feb;18(2):171-88. [2]. Schumacher WA, et al. Antiplatelet activity of the long-acting thromboxane receptor antagonist BMS 180,291 in monkeys. Prostaglandins. 1992 Nov;44(5):389-97.