138949-73-2

138949-73-2 structure

Name: Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt
Chemical Name: thr-arg-ser-ala-trp
CAS Number: 138949-73-2
Molecular Formula: C₂₇H₄₁N₉O₈
Molecular Weight: 619.67
Catalog: Biochemical Peptide
Create Date: 2018-06-11 20:13:22
Modify Date: 2025-08-25 19:04:55
Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].

Name	thr-arg-ser-ala-trp
Synonyms	Osteostain PARATHYROID HORMONE-RELATED PROTEIN (107-111) OSTEOSTATIN MFCD00133747 PTH RELATED PEPTIDE (107-111) OSTEOSTATIN (HUMAN,RAT) PTHRP (107-111) PTH-RP (107-111) (HUMAN,RAT) PTH-RELATED PROTEIN (107-111) (HUMAN,RAT)

Description	Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].
Related Catalog	Signaling Pathways >> Others >> Others
References	[1]. Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. [2]. Ibáñez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. [3]. Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. [4]. Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845.