74027-99-9

74027-99-9 structure

Name: 4-Hydroxyphenyl-dimethyl-phenylsilan
Chemical Name: 4-Hydroxyphenyl-dimethyl-phenylsilan
CAS Number: 74027-99-9
Molecular Formula: C₁₄H₁₆OSi
Molecular Weight: 228.36200
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-12 21:47:22
Modify Date: 2024-02-27 18:09:02
Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC50s of 13, 5µM for ERα and Erβ, respectively[1].

Name	4-Hydroxyphenyl-dimethyl-phenylsilan
Synonyms	4-phenyldimethylsilylphenole

Description	Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC50s of 13, 5µM for ERα and Erβ, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Metabolic Disease
Target	ERα:13 μM (IC50) ERβ:5 μM (IC50)
References	[1]. Saito H, et al. Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives. Bioorg Med Chem. 2020 Feb 15;28(4):115310.