87626-56-0

87626-56-0 structure

Name: LM985
Chemical Name: 2-(diethylamino)ethyl 2-(4-oxo-2-phenylchromen-8-yl)acetate
CAS Number: 87626-56-0
Molecular Formula: C₂₃H₂₅NO₄
Molecular Weight: 379.44900
Catalog: Research Areas Cancer
Create Date: 2017-03-01 02:03:41
Modify Date: 2025-08-25 12:59:16
LM985 is one of a series of compounds based on the flavone ring structure, with anti-tumor activities.

Name	2-(diethylamino)ethyl 2-(4-oxo-2-phenylchromen-8-yl)acetate
Synonyms	lm 985 LM985

Description	LM985 is one of a series of compounds based on the flavone ring structure, with anti-tumor activities.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	LM985 shows inhibitory effects against MAC 13 cells, but MAC 15A cells are less sensitive to LM985[1].
In Vivo	LM985 (200 mg/kg, s.c.) shows moderate activity against MAC 13, and after repeated injection 7 days, responses are considerably enhanced[2].
References	[1]. M. C. Bibby, et al. Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). Br J Cancer. 1987 Feb; 55(2): 159-163. [2]. J. A. Double, et al. Pharmacokinetics and anti-tumour activity of LM985 in mice bearing transplantable adenocarcinomas of the colon. Br J Cancer. 1986 Oct; 54(4): 595-600.