196961-43-0

196961-43-0 structure

Name: CD 3254
Chemical Name: 3-[4-hydroxy-3-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)phenyl]prop-2-enoic acid
CAS Number: 196961-43-0
Molecular Formula: C₂₄H₂₈O₃
Molecular Weight: 364.47700
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2016-04-25 13:52:07
Modify Date: 2024-01-04 19:20:18
CD3254 a potent and selective retinoid-X-receptor (RXR) agonist[1].

Name	3-[4-hydroxy-3-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)phenyl]prop-2-enoic acid

Description	CD3254 a potent and selective retinoid-X-receptor (RXR) agonist[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RXR
In Vitro	CD3254 induces similar phenotypes of malformations after 5 days exposure at low concentration (20 μg/L) to those after the 1st d exposure at high concentrations (50 and 100 μg/L)[1]. Cell Viability Assay[1] Cell Line: zebrafish (Danio rerio) embryos Concentration: 10, 20, 50, 100 μg/L Incubation Time: Result: The percent of survival decreased by 19.1 % in 100 μg/L CD3254-treated group after the 1st day exposure. The embryos did not hatch in groups exposed to 100 μg/L CD3254 for 5 days or to 1 mg/L CD3254 for the 1st day.
References	[1]. Nahoum V, et al. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17323-8.