- DC Chemicals Limited
- China
- Product Name: Anecortave Acetate
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Pregna-4,9(11)-diene-3,20-dione,21-(acetyloxy)-17-hydroxy-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Anecortave Acetate
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
7753-60-8
7753-60-8 structure
- Name: Anecortave Acetate
- Chemical Name: [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- CAS Number: 7753-60-8
- Molecular Formula: C23H30O5
- Molecular Weight: 386.48100
- Catalog: Signaling Pathways Metabolic Enzyme/Protease PAI-1
- Create Date: 2018-09-01 17:43:01
- Modify Date: 2024-01-04 23:27:30
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Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].
| Name | [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
|---|---|
| Synonyms |
2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion Retaane 21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione AL-3789 2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate Anecortave Anecortave acetate Retaane suspension |
| Description | Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PAI-1[2] |
| In Vivo | Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2]. Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2] Dosage: 5 μl of a 10% suspension of Anecortave acetate Administration: Injected into eyes Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels. Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection. |
| Density | 1.23g/cm3 |
|---|---|
| Boiling Point | 551.8ºC at 760 mmHg |
| Molecular Formula | C23H30O5 |
| Molecular Weight | 386.48100 |
| Flash Point | 188.4ºC |
| Exact Mass | 386.20900 |
| PSA | 80.67000 |
| LogP | 3.30170 |
| Index of Refraction | 1.572 |
| Precursor 8 | |
|---|---|
| DownStream 5 | |
![(8S,9R,10S,13S,14S,17R)-17-(2-acetoxyacetyl)-9-chloro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl nicotinate structure](https://www.chemsrc.com/caspic/279/108674-98-2.png)
