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480-37-5

480-37-5 structure
480-37-5 structure
  • Name: Pinocembrin-7-methyl ether
  • Chemical Name: pinostrobin
  • CAS Number: 480-37-5
  • Molecular Formula: C16H14O4
  • Molecular Weight: 270.280
  • Catalog: Natural product Flavonoids
  • Create Date: 2018-02-27 08:00:00
  • Modify Date: 2024-01-08 17:25:58
  • Pinostrobin is a flavonoid can be found in many plants, and has anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective properties. Pinostrobin is a potent PCSK9 inhibitor and inhibits the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management[1].

Name pinostrobin
Synonyms Dihydrotectochrysin
4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (S)-
Pinostrobin
2-Phenyl-5-hydroxy-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one
(S)-5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
Pistrobin
Pinocembrin-7-methyl ether
5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one
(2S)-5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one
Pinostobin
4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (2S)-
Description Pinostrobin is a flavonoid can be found in many plants, and has anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective properties. Pinostrobin is a potent PCSK9 inhibitor and inhibits the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management[1].
Related Catalog
Target

IC50: PCSK9[1]

References

[1]. Gao WY, et al. Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells.J Agric Food Chem. 2018 Jun 20;66(24):6083-6093.

Density 1.3±0.1 g/cm3
Boiling Point 494.9±45.0 °C at 760 mmHg
Melting Point 100ºC
Molecular Formula C16H14O4
Molecular Weight 270.280
Flash Point 188.8±22.2 °C
Exact Mass 270.089203
PSA 55.76000
LogP 4.11
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.612
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2932999099
HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%