22994-85-0
22994-85-0 structure
- Name: Benznidazole
- Chemical Name: Benznidazole
- CAS Number: 22994-85-0
- Molecular Formula: C12H12N4O3
- Molecular Weight: 260.24900
- Catalog: Signaling Pathways Anti-infection Parasite
- Create Date: 2018-02-20 08:00:00
- Modify Date: 2025-08-24 19:01:25
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Benznidazol (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease[1][2].
| Name | Benznidazole |
|---|---|
| Synonyms |
MFCD00243089
N-benzyl-2-(2-nitroimidazol-1-yl)acetamide 1H-Imidazole-1-acetamide,2-nitro-N-(phenylmethyl)- |
| Description | Benznidazol (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease[1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart, in mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate and treated at 180 days post infection (p.i.) (i.e. chronic phase) with Benznidazole[1]. Animal Model: Mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12[1] Dosage: 100 mg/kg/day Administration: Orally for 30 days Result: Produced a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart. |
| References |
| Density | 1.35g/cm3 |
|---|---|
| Melting Point | 189-192ºC(lit.) |
| Molecular Formula | C12H12N4O3 |
| Molecular Weight | 260.24900 |
| Exact Mass | 260.09100 |
| PSA | 92.74000 |
| LogP | 2.02180 |
| Index of Refraction | 1.643 |
| Storage condition | -20℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | NI3340000 |
| HS Code | 2933290090 |
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |