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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-chloro-9-[[3-[(2-chloroethyl)ethylamino]propyl]amino]-2-methoxyacridine dihydrochloride
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146-59-8

146-59-8 structure

146-59-8 structure

Name: 6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE
Chemical Name: icr-170
CAS Number: 146-59-8
Molecular Formula: C₂₁H₂₇Cl₄N₃O
Molecular Weight: 479.27100
Create Date: 2018-12-10 19:08:10
Modify Date: 2025-08-26 11:55:07

Name	icr-170
Synonyms	MFCD00012658 acridine mutagen ICR 170 dihydrochloride 6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE ICR 170 ACRIDINE MUTAGEN*DIHYDROCHLORIDE 9-(3-(ethyl(2-chloroethyl)amino)propylamino)-6-chloro-2-methoxyacridinedihyd 6-chloro-9-(3-n-(2-chloroethyl)ethylamino]propylamino-2-methoxyacridine.2 icr170 EINECS 205-675-7 ACRIDINEICR170 6-chloro-9-(3-(n-(2-chloroethyl)-n-ethylamino)propylamino)-2-methoxy-acridin acridinemustard

Boiling Point	546.9ºC at 760mmHg
Melting Point	231-232ºC
Molecular Formula	C₂₁H₂₇Cl₄N₃O
Molecular Weight	479.27100
Flash Point	284.5ºC
Exact Mass	477.09100
PSA	37.39000
LogP	7.08970
Vapour Pressure	5.17E-12mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7680000

CHEMICAL NAME :: Acridine, 6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propyla mino)-2-methoxy-, dihydrochloride

CAS REGISTRY NUMBER :: 146-59-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 47

MOLECULAR FORMULA :: C21-H25-Cl2-N3-O.2Cl-H

MOLECULAR WEIGHT :: 479.31

WISWESSER LINE NOTATION :: T C666 BNJ EG IM3N2&2G LO1 &GH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD20 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 ug/kg/28D-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 4 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 8,113,1974

Hazard Codes	T: Toxic;
Risk Phrases	68-40-23/24/25
Safety Phrases	S22;S45;S36/S37/S39
RIDADR	UN 2811
Packaging Group	III
Hazard Class	6.1(b)

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