Name | Tiron |
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Synonyms |
MFCD00149531
Pyrocatechol-3,5-disulfonic Acid Disodium Salt Monohydrate 4,5-dihydroxybenzene-1,3-disulfonic acid disodium salt tlron disodium 1,2-dihydroxybenzene-3,5-disulfonate 1,3-Benzenedisulfonic acid, 4,5-dihydroxy-, disodium salt Tiron 4,5-Dihydroxy-1,3-benzenedisulfonic acid disodium salt TIRON(TM) Disodium 4,5-dihydroxy-1,3-benzenedisulfonate Disodium-1,2-dihydroxybenzene-3,5-disulfonate YOE'S REAGENT Sodium 4,5-dihydroxybenzene-1,3-disulfonate hydrate tiferron Tiferron Monohydrate Disodium 4,5-Dihydroxybenzene-1,3-disulfonate Monohydrate 1,3-Benzenedisulfonic acid, 4,5-dihydroxy-, sodium salt (1:2) Disodium 4,5-dihydroxybenzene-1,3-disulfonate Sodium Pyrocatechol-2,4-disulfonate sdd EINECS 205-741-5 sodium catechol disulfonate Pyrocatechol-3,5-disulfonic acid disodium salt 1,2-dihydroxybenzene-3,5-disulfonic acid disodium salt Tiron TIRON(R) Catechol-3,5-disulfonic Acid Disodium Salt Monohydrate |
Description | Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals[1][2][3]. |
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Related Catalog | |
In Vitro | Tiron (10 mM) 保护中国仓鼠 V79 细胞免受 H2O2 诱导的细胞毒性[1]。 Tiron (0-20 mM) 保护超螺旋 DNA 免受金属介导的超氧化物依赖性链断裂[1]。 Tiron (50 nM-200 nM, 48 h) 抑制 HG 诱导的新生大鼠心肌细胞凋亡[3]。 Tiron (50 nM-200 nM, 48 h) 降低新生大鼠心肌细胞内的骨桥蛋白[3]。 Tiron (0.2 mM,2 小时) 抑制 UVB 诱导的 HDF 中 MMP-1 和 MMP-3 的上调[4]。 Tiron (0.7 mM,48 小时) 增加 S 期和 G2/M 期 PT4 细胞的百分比[5]。 Cell Cycle Analysis[5] Cell Line: PT4 cells Concentration: 0.7 mM Incubation Time: 48 h Result: Increased the percentage of PT4 cells in S and G2/M phases, along with a reduction of cells in the G0/G1 phase. |
In Vivo | Tiron (200 mg/kg,灌胃) 改善小鼠气道重塑模型中的氧化应激和炎症[2]。 Tiron (300 mg/kg,i.p.,每日一次,持续两周) 减轻了 STZ 诱导的糖尿病小鼠左心室心肌细胞的凋亡[3]。 Animal Model: BALB/c mice challenged with Ovalbumin (OVA) aerosol for 8 weeks[2] Dosage: 200 mg/kg Administration: Oral gavage. Result: Inhibited levels of NOx, IL-13 and TGF-β1, and immunoreactivity of NF-κB. Animal Model: STZ-induced diabetic mice[3] Dosage: 300 mg/kg Administration: i.p., daily for two weeks. Result: Reduced the levels of total oxidized proteins and advanced glycation end products (AGEs)-related proteins. Inhibited cardiac myocyte apoptosis. Decreased PKCδ localization on plasma membrane. |
References |
Melting Point | 300 °C |
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Molecular Formula | C6H6Na2O9S2 |
Molecular Weight | 314.201 |
Exact Mass | 313.914307 |
PSA | 180.85000 |
LogP | 1.00330 |
Stability | Stable. Incompatible with strong oxidizing agents. |
Water Solubility | soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Hazard Codes | Xi:Irritant; |
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Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36 |
WGK Germany | 3 |
RTECS | CZ9263000 |
HS Code | 29082000 |
~73% 149-45-1 |
Literature: DRATHS CORPORATION; FROST, John, W.; BUI, Vu Patent: WO2011/22588 A1, 2011 ; Location in patent: Page/Page column 8 ; |
Precursor 1 | |
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DownStream 0 |
HS Code | 2908999090 |
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Summary | 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |