DC Chemicals Limited
China
Product Name: PMEDAP
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

113852-41-8

113852-41-8 structure

Name: PMEDAP
Chemical Name: 2-(2,6-diaminopurin-9-yl)ethoxymethylphosphonic acid
CAS Number: 113852-41-8
Molecular Formula: C₈H₁₃N₆O₄P
Molecular Weight: 288.20
Catalog: Signaling Pathways Anti-infection CMV
Create Date: 2016-12-26 12:18:10
Modify Date: 2024-01-13 21:41:02
PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality[1][2].

Name	2-(2,6-diaminopurin-9-yl)ethoxymethylphosphonic acid
Synonyms	{[2-(2,6-diamino-9h-purin-9-yl)ethoxy]methyl}phosphonic acid N-(2-Phosphonomethoxyethyl)-2,6-diaminopurine 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine 5-(3-Hydroxy-2-phosphonomethoxypropyladenine) PME-DAP Phosphonic acid,((2-(2,6-diamino-9H-purin-9-yl)ethoxy)methyl) PMEDAP

Description	PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> CMV
In Vivo	PMEDAP (0.25-5 mg/kg; IP; daily; starting on the day of MSV-infected and continuing for an additional four days) causes a dose-dependent suppression of tumor formation and mortality in newborn mice inoculated with MSV[1]. Animal Model: Three-week-old male NMRI mice[1] Dosage: 0.25 mg/kg, 1 mg/kg, 5 mg/kg Administration: IP; daily; starting on the day of infection and continuing for an additional four days Result: Effected a significant delay in tumor appearance and an enhancement of the survival rate of tumor-bearing mice.
References	[1]. Neyts J, et al. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo [published correction appears in Eur J Clin Microbiol Infect Dis 1993 Jul;12(7):following 477]. Eur J Clin Microbiol Infect Dis. 1993;12(6):437-446. [2]. Naesens L, et al. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis. 1989;8(12):1043-1047.

Density	2.03g/cm3
Boiling Point	748.7ºC at 760mmHg
Molecular Formula	C₈H₁₃N₆O₄P
Molecular Weight	288.20
Flash Point	406.6ºC
Exact Mass	288.07400
PSA	172.94000
Vapour Pressure	1.51E-23mmHg at 25°C
Index of Refraction	1.826

Hazard Codes	Xi