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7182-54-9

7182-54-9 structure
7182-54-9 structure
  • Name: Monactin
  • Chemical Name: Monactin
  • CAS Number: 7182-54-9
  • Molecular Formula: C41H66O12
  • Molecular Weight: 750.95600
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2017-08-23 23:53:39
  • Modify Date: 2024-01-09 11:37:49
  • Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].
Name Monactin
Synonyms Nonactin,5-demethyl-5-ethyl
5-ethyl-2,11,14,20,23,29,32-heptamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
Akd-1B
Description Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].
Related Catalog
In Vitro Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3]. Monactin inhibits TCF/β-catenin transcriptional activity[4]. At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5].
In Vivo Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1].
References

[1]. Graven SN, et al. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Biochemistry. 1966;5(5):1735-1742.

[2]. Murer H, et al. On the mechanism of sugar and amino acid interaction in intestinal transport. J Biol Chem. 1975;250(18):7392-7396.

[3]. Harinantenaina Rakotondraibe L, et al. Antiproliferative and antiplasmodial compounds from selected Streptomyces species. Bioorg Med Chem Lett. 2015;25(23):5646-5649.

[4]. Tamai, Y, et al. Nonactin and related compounds found in a screening program for wnt signal inhibitory activity. Heterocycles, 84(2), 1245-1250.

[5]. Harold FM, et al. Effects of nigericin and monactin on cation permeability of Streptococcus faecalis and metabolic capacities of potassium-depleted cells. J Bacteriol. 1968;95(3):816-823.
Density 1.035g/cm3
Boiling Point 896.9ºC at 760 mmHg
Molecular Formula C41H66O12
Molecular Weight 750.95600
Flash Point 353.8ºC
Exact Mass 750.45500
PSA 142.12000
LogP 6.41210
Index of Refraction 1.451

Chemsrc provides CAS#:7182-54-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 7182-54-9 | Chemsrc address: https://www.chemsrc.com/en/baike/364531.html

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