133-16-4

133-16-4 structure

Name: 2-Diethylaminoethyl 4-amino-2-chloro-benzoate
Chemical Name: chloroprocaine
CAS Number: 133-16-4
Molecular Formula: C₁₃H₂₀Cl₂N₂O₂
Molecular Weight: 307.21600
Create Date: 2018-09-26 20:05:01
Modify Date: 2025-08-22 18:50:17
Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine blocks peripheral nerve[1].

Name	chloroprocaine
Synonyms	2-(diethylamino)ethyl 4-amino-2-chlorobenzoate Chloroprocainum Piocaine Chloroprocain Nesacaine Chlorprocain 2-Chloroprocaine Halestyn Chlorprocainum Chlorprocaine CHLOROPROCAINE

Description	Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine blocks peripheral nerve[1].
Target	IC50: 13 mM (Na,K-ATPase)[1]
In Vivo	In mice, the intravenous LD50 of Chloroprocaine HCl is 97 mg/kg and the subcutaneous LD50 of Chloroprocaine HCl is 950 mg/kg[2].
References	[1]. H Kutchai, et al. Inhibition of the Na,K-ATPase of Canine Renal Medulla by Several Local Anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403. [2]. Chloroprocaine HCl Injection.

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9329 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 48 (estimated) No. of Female Employees: 48 (estimated)

HS Code	2922499990

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%