Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)
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4299-60-9

4299-60-9 structure

Name: N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)
Chemical Name: 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide,2-(2-hydroxyethylamino)ethanol
CAS Number: 4299-60-9
Molecular Formula: C₁₅H₂₄N₄O₅S
Molecular Weight: 372.44000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-03-06 00:05:07
Modify Date: 2025-10-19 06:51:40
Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].

Name	4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide,2-(2-hydroxyethylamino)ethanol
Synonyms	NU-445 N-(3,4-Dimethylisoxazol-5-yl)sulphanilamide,compound with 2,2'-iminodiethanol (1:1) Sulfafurazol 2,2'-imidodiethanol Benzenesulfonamide,4-amino-N-(3,4-dimethyl-5-isoxazolyl)-,compd. with 2,2'-iminobis(ethanol) (1:1) EINECS 224-308-1 N(sup 1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide compound with 2,2'-iminodiethanol (1:1) SULFISOXAZOLE DIOLAMINE Sulfisoxazole diolamine (USAN)

Description	Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Signaling Pathways >> Anti-infection >> Bacterial
Target	ETA:0.60 μM (IC50) ETB:22 μM (IC50)
References	[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34. [2]. Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387.