934182-09-9

934182-09-9 structure

Name: CYPMPO
Chemical Name: 2-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-1-hydroxy-2-methyl-3,4-dihydro-2H-1λ5-pyrrol-1-yl
CAS Number: 934182-09-9
Molecular Formula: C₁₀H₁₈NO₄P
Molecular Weight: 247.23
Catalog: Research Areas Cancer
Create Date: 2017-04-12 17:03:53
Modify Date: 2024-02-01 09:29:13
CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity[1].

Name	2-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-1-hydroxy-2-methyl-3,4-dihydro-2H-1λ5-pyrrol-1-yl
Synonyms	5-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)-1-METHYL-1H-PYRAZOLE 2H-Pyrrol-1-yl, 2-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,1,3,4-tetrahydro-1-hydroxy-2-methyl- 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl)-5-methyl-1-pyrroline-N-oxide 2-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-1-hydroxy-2-methyl-3,4-dihydro-2H-1λ-pyrrol-1-yl 2-methyl-2-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl)-3,4-dihydro-2H-pyrrole 1-oxide 1-Methyl-1H-pyrazole-5-boronic acid,neopentyl glycol ester 5-(2,2-dimethyl-1,3-propoxycyclophosphoryl)-5-methyl-1-pyrroline N-oxide

Description	CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	"DMPO is often used as a spin trapping agent to detect oxygen-centered radicals. CYPMPO has a larger reaction rate constant with superoxide anion than DMPO and the superoxide adduct of CYPMPO is more stable than that of DMPO. CYPMPO (2.5 mM) acts as a spin-trap agent[2]. CYPMPO, a spin-trap, a cyclic DEPMPO-like nitrone trap, may provide new free radical information when used with mitochondria. CYPMPO has the preferential quality of having minimal mitochondrial toxicity at concentrations required for radical detection[3]. "
References	[1]. Masato Kamibayashi, et al. Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO). Free Radic Res. 2006 Nov;40(11):1166-72. [2]. Ryohei Umeda, et al. Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors. J Clin Biochem Nutr. 2019 Jan;64(1):20-26. [3]. Matsuzaki S, et al. Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry 2011, 50, 50, 10792-10803.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport

902503-51-9

~53%

934182-09-9

4090-60-2

934182-09-9

Precursor 1
4090-60-2
DownStream 0