446022-33-9

446022-33-9 structure

Name: Pelitrexol
Chemical Name: N-((5-(2-((6S)-2-Amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl)-4-methyl-2-thienyl)carbonyl)-L-glutamic acid
CAS Number: 446022-33-9
Molecular Formula: C₂₀H₂₅N₅O₆S
Molecular Weight: 463.507
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
Create Date: 2018-08-19 08:47:12
Modify Date: 2025-08-23 10:36:17
Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT).

Name	N-((5-(2-((6S)-2-Amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl)-4-methyl-2-thienyl)carbonyl)-L-glutamic acid
Synonyms	L-Glutamic acid, N-[[5-[2-[(6S)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-4-methyl-2-thienyl]carbonyl]- N-[(5-{2-[(6S)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}-4-methyl-2-thienyl)carbonyl]-L-glutamic acid (2S)-2-(((5-(2-((6S)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido(2,3-D)pyrimidin-6-yl)ethyl)-4-methylthiophen-2-yl)carbonyl)amino)pentanedioic acid Ag2037 Pelitrexol Unii-dht6E8m4kp L-Glutamic acid,N-((5-(2-((6S)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)-4-methyl-2-thienyl)carbonyl)

Description	Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT).
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	GARFT[1]
References	[1]. Emmanuel N, et al. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 Jun 27;19(13):2665-2680.