118292-41-4

118292-41-4 structure

Name: Tazarotenic Acid
Chemical Name: tazarotenic acid
CAS Number: 118292-41-4
Molecular Formula: C₁₉H₁₇NO₂S
Molecular Weight: 323.409
Catalog: Research Areas Others
Create Date: 2018-12-30 18:57:36
Modify Date: 2025-08-24 21:52:50
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].

Name	tazarotenic acid
Synonyms	Tazarotenic Acid 3-Pyridinecarboxylic acid, 6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylic acid 6-[(4,4-Dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinic acid

Description	Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].
Related Catalog	Research Areas >> Others
In Vivo	Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1] . Male Female Male Dose (mg kg-1) 4.4 4.4 0.49 AUC (μg h mL-1) 9.31 (2.14) 9.78 (1.36) 0.594 (0.95) CL (mL min-1 kg-1) 7.96 (1.59) 7.62 (0.85) 14.0 (2.2) k (h-1) 0.562 (0.339) 0.820 (0.146) 0.741 (0.115) T1/2 (h) 1.64 (0.92) 0.86 (0.14) 0.95 (0.16) V0 (L kg-1) 0.43 (0.05) 0.49 (0.06) 1.31 (1.15) Vβ (L kg-1) - - 1.14 (0.09) Vmax (μg min-1) 9.08 (2.89) 6.09 (1.22) - Km (μg mL-1) 7.09 (1.35) 5.12 (1.19) -
References	[1]. Chandraratna RA. Tazarotene--first of a new generation of receptor-selective retinoids. Br J Dermatol. 1996;135 Suppl 49:18-25. [2]. Hsyu PH, et al. Pharmacokinetics of a novel retinoid AGN 190168 and its metabolite AGN 190299 after intravenous administration of AGN 190168 to rats. Biopharm Drug Dispos. 1994;15(5):347-357. [3]. Abramovits W, et al. Treatment of warty dyskeratoma with tazarotenic acid. J Am Acad Dermatol. 2002;46(2 Suppl Case Reports):S4.

952294-17-6

118292-41-4

Literature: US2007/238881 A1, ; Page/Page column 6 ;

Precursor 0
DownStream 1
118292-40-3