4450-98-0

4450-98-0 structure

Name: EBPC
Chemical Name: 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester
CAS Number: 4450-98-0
Molecular Formula: C₁₄H₁₅NO₄
Molecular Weight: 261.27
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldose Reductase
Create Date: 2017-03-06 10:49:14
Modify Date: 2025-09-18 22:35:31
EBPC is a potent and selective aldose reductase inhibitor with an IC50 of 47 nM[1].

Name	1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester
Synonyms	ethyl 1-benzyl-3-hydroxy-3-pyrrolin-2-one-4-carboxylate Ethyl 1-benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate 1-benzyl-3-hydroxy-2-oxo-3-pyrroline-4-carboxylic acid ethyl ester 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester 1-Ebpc 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-1H-pyrrole-3-carboxylic acid ethyl ester CP-10668 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester

Description	EBPC is a potent and selective aldose reductase inhibitor with an IC50 of 47 nM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Research Areas >> Metabolic Disease
References	[1]. Mylari BL, et al. A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. J Med Chem. 1991 Mar;34(3):1011-8.

Density	1.3±0.1 g/cm3
Boiling Point	479.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₅NO₄
Molecular Weight	261.27
Flash Point	244.0±28.7 °C
Exact Mass	261.100098
PSA	66.84000
LogP	1.34
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.615

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318
Precautionary Statements	P280-P305 + P351 + P338
RIDADR	NONH for all modes of transport
HS Code	2933990090

23583-21-3

95-92-1

4450-98-0

Literature: Coumar, Mohane Selvaraj; Wu, Jian-Sung; Leou, Jiun-Shyang; Tan, Uan-Kang; Chang, Chung-Yu; Chang, Teng-Yuan; Lin, Wen-Hsing; Hsu, John T.-A.; Chao, Yu-Sheng; Wu, Su-Ying; Hsieh, Hsing-Pang Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 5 p. 1623 - 1627

Precursor 2
23583-21-3 95-92-1
DownStream 1
53720-95-9

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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