Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (7S)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

2731-16-0

2731-16-0 structure

Name: Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (7S)-
Chemical Name: (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one
CAS Number: 2731-16-0
Molecular Formula: C₂₀H₂₃NO₄S
Molecular Weight: 373.46600
Create Date: 2017-08-11 07:11:46
Modify Date: 2025-08-27 20:34:58

Name	(7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one
Synonyms	N-Deacetylmethylthiocolchicine Desacetyl thiocolchicine (S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one deacetyl-10-thiocolchicine N-deacetyl thiocolchicine Colchicine,N-deacetyl-thio Thiolcolciran 7-deacetylthiocolchicine Corps R. 261 N-Desacetylthiocolchicine Thio-colciran Deacetylthiocolchicine

Density	1.27g/cm3
Boiling Point	631.6ºC at 760mmHg
Molecular Formula	C₂₀H₂₃NO₄S
Molecular Weight	373.46600
Flash Point	335.8ºC
Exact Mass	373.13500
PSA	96.08000
LogP	4.10780
Vapour Pressure	7.33E-16mmHg at 25°C
Index of Refraction	1.624

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0875000

CHEMICAL NAME :: Colchicine, N-deacetyl-10-thio-

CAS REGISTRY NUMBER :: 2731-16-0

BEILSTEIN REFERENCE NO. :: 2822164

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C20-H23-N-O4-S

MOLECULAR WEIGHT :: 373.50

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JZ NS1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 71 ug/kg/D

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Blood - leukopenia

REFERENCE :: BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer. (Paris, France) V.1-52, 1908-65. For publisher information, see BUCABS. Volume(issue)/page/year: 42,308,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 98,479,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 98,479,1958

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2000 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 15,533,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer. (Paris, France) V.1-52, 1908-65. For publisher information, see BUCABS. Volume(issue)/page/year: 42,308,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 107,150,1956 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 6 mg/kg

SEX/DURATION :: female 13-14 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 166,435,1972

HS Code	2930909090

2730-71-4

~66%

2731-16-0

Literature: Lee, Sun-Hee; Park, Sun-Kyoung; Kim, Jeong-Mi; Kim, Myung-Hwa; Kim, Kwang-Hee; Chun, Kwang-Woo; Cho, Kyung-Hea; Youn, Ji-Youn; Namgoong, Sung Keon Archiv der Pharmazie, 2005 , vol. 338, # 12 p. 582 - 589

64-86-8

2731-16-0

Literature: Chang, Dong-Jo; Kim, Wan-Joo Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 14 p. 3121 - 3125

203584-67-2

~10%

2731-16-0

Literature: Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282

209810-38-8

2731-16-0

Literature: Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282

209810-39-9

2731-16-0

Literature: Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282

2731-16-0

Literature: Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282

Precursor 4
2730-71-4 64-86-8 209810-38-8 2731-16-0
DownStream 8
2731-16-0 2730-71-4 75776-08-8 76129-11-8
76129-16-3 92264-45-4 97043-05-5 63620-51-9

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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