116289-53-3

116289-53-3 structure

Name: Tulopafant
Chemical Name: N-(3-benzoylphenyl)-3-pyridin-3-yl-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carboxamide
CAS Number: 116289-53-3
Molecular Formula: C₂₅H₁₉N₃O₂S
Molecular Weight: 425.50200
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-07-19 15:44:46
Modify Date: 2024-01-05 14:26:59
Tulopafant is a platelet activating factor (PAF) antagonist.

Name	N-(3-benzoylphenyl)-3-pyridin-3-yl-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carboxamide
Synonyms	Tulopafant Tulopafantum UNII-IQ3Q8N1287

Description	Tulopafant is a platelet activating factor (PAF) antagonist.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease
In Vitro	Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence produced by PAF primed cells[1].
In Vivo	Tulopafant (RP 59227) effectively reduces myocardial infarct size and reduces the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs[1].Histological examination reveals marked diminution of both interstitial hemorrhage and deposition of platelet and granulocytes in capillaries of cardiac xenografts when recipient animals are pretreated with Tulopafant[2].
References	[1]. Auchampach JA, et al. Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. Basic Res Cardiol. 1998 Oct;93(5):361-71. [2]. O'Hair DP, et al. Tulopafant, a PAF receptor antagonist, increases capillary patency and prolongs survival in discordant cardiac xenotransplants. J Lipid Mediat. 1993 May;7(1):79-84.