Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: Ferriprox
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao
Related CAS#:
30652-11-0 1346601-82-8
141675-48-1

30652-11-0

30652-11-0 structure
30652-11-0 structure
  • Name: Deferiprone
  • Chemical Name: deferiprone
  • CAS Number: 30652-11-0
  • Molecular Formula: C7H9NO2
  • Molecular Weight: 139.152
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Hydroxypyridine
  • Create Date: 2018-07-24 00:21:55
  • Modify Date: 2024-01-02 11:51:32
  • Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload. Target：Deferiprone is an orphan drug designed and developed primarily by academic initiatives for the treatment of iron overload in thalassaemia. Deferiprone has been used in several other iron or other metal imbalance conditions and has prospects of wider clinical applications. Deferiprone has high affinity for iron and interacts with almost all the iron pools at the molecular, cellular, tissue and organ levels. Doses of 50-120 mg/kg/day appear to be effective in bringing patients to negative iron balance. Deferiprone increases urinary iron excretion, which mainly depends on the iron load of patients and the dose of the drug.
Name deferiprone
Synonyms 1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE
3-hydroxy-1,2-dimethyl-pyrid-4-one
UNII-2BTY8KH53L
3-hydroxy-1,2-dimethylpyridin-4(1H)-one
Deferiprone
deferipnone
3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE
Ferriprox
3-hydroxy-1,2-dimethyl-4-pyridinone
DMHP
DEFERIPRON
CP20
cp20(chelatingagent)
3-hydroxy-1,2-dimethyl-4-pyridone
1,2-dimethyl-3-hydroxy-4(1H)-pyridinone
3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone
Kelfer
1,2-dimethyl-3-hydroxy-4-pyridinone
1,2-Dimethyl-3-hydroxy-4-pyridone
4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-
Deferione
DEFERIDONE
MFCD00134497
Description Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload. Target：Deferiprone is an orphan drug designed and developed primarily by academic initiatives for the treatment of iron overload in thalassaemia. Deferiprone has been used in several other iron or other metal imbalance conditions and has prospects of wider clinical applications. Deferiprone has high affinity for iron and interacts with almost all the iron pools at the molecular, cellular, tissue and organ levels. Doses of 50-120 mg/kg/day appear to be effective in bringing patients to negative iron balance. Deferiprone increases urinary iron excretion, which mainly depends on the iron load of patients and the dose of the drug.
Related Catalog
References

[1]. Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584.
Density 1.2±0.1 g/cm3
Boiling Point 232.7±40.0 °C at 760 mmHg
Melting Point 272-275 °C(lit.)
Molecular Formula C7H9NO2
Molecular Weight 139.152
Flash Point 94.5±27.3 °C
Exact Mass 139.063324
PSA 42.23000
LogP -0.22
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.565
Storage condition -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU7785940
CHEMICAL NAME :
4(1H)-Pyridinone, 1,2-dimethyl-3-hydroxy-
CAS REGISTRY NUMBER :
30652-11-0
BEILSTEIN REFERENCE NO. :
1447108
LAST UPDATED :
199803
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C7-H9-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Cardiac - other changes
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 18,202,1996
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,413,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
983 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO 63379) V.1- 1946- Volume(issue)/page/year: 76,2389,1990
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse, Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year: 10,247,1997
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 18,202,1996 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 mg/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Endocrine - changes in thymus weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 28(Suppl A),73,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
52 gm/kg/52W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 28(Suppl A),81,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8400 mg/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Endocrine - changes in thymus weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 28(Suppl A),73,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 gm/kg/12W-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO 63379) V.1- 1946- Volume(issue)/page/year: 78,2727,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3600 mg/kg/28D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Related to Chronic Data - death
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse, Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year: 10,247,1997
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
10500 mg/kg/35W-I
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction Liver - hepatitis (hepatocellular necrosis), diffuse Blood - changes in leukocyte (WBC) count
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse, Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year: 10,247,1997
Hazard Codes Xn:Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36
WGK Germany 3
RTECS UU7785940
HS Code 2933399090
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chemsrc provides CAS#:30652-11-0 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 30652-11-0 | Chemsrc address: https://www.chemsrc.com/en/baike/331098.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved