134036-53-6

134036-53-6 structure

Name: AG-370
Chemical Name: 3-amino-4-(1H-indol-5-ylmethylidene)pent-2-ene-1,1,5-tricarbonitrile
CAS Number: 134036-53-6
Molecular Formula: C₁₅H₉N₅
Molecular Weight: 259.266
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PDGFR
Create Date: 2017-04-22 15:34:55
Modify Date: 2024-01-13 15:56:06
AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].

Name	3-amino-4-(1H-indol-5-ylmethylidene)pent-2-ene-1,1,5-tricarbonitrile
Synonyms	(3E)-2-Amino-4-(1H-indol-5-yl)buta-1,3-diene-1,1,3-tricarbonitrile 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(1H-indol-5-yl)-, (3Z)- 3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE 2-amino-4-(1HA-indol-5-yl)-1,1,3-tricyanobuta-1,3-diene 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(1H-indol-5-yl)-, (3E)- (3E)-2-Amino-4-(1H-indol-5-yl)-1,3-butadiene-1,1,3-tricarbonitrile 2-amino-4-(1H-indol-5-yl)-1,1,3-tricyanobuta-1,3-diene (3Z)-2-Amino-4-(1H-indol-5-yl)-1,3-butadiene-1,1,3-tricarbonitrile

Description	AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR
Target	PDGFR:20 μM (IC50)
In Vitro	AG 370 blocks mitogenesis induced by epidermal growth factor (IC50 of 50 μM) and human serum (IC50 of 50 μM)[1][1]. In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor[1][1].
References	[1]. M C Bryckaert, et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp Cell Res. 1992 Apr;199(2):255-61.