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35121-78-9 63859-31-4
61849-14-7

35121-78-9

35121-78-9 structure
35121-78-9 structure
  • Name: Epoprostenol
  • Chemical Name: prostaglandin I2
  • CAS Number: 35121-78-9
  • Molecular Formula: C20H31NaO5
  • Molecular Weight: 374.44700
  • Catalog: API Hormone and endocrine-regulating drugs Prostaglandins
  • Create Date: 2018-09-17 00:32:08
  • Modify Date: 2024-01-09 09:37:29
  • Epoprostenol (Prostaglandin I2), the synthetic form of the natural prostaglandin derivative Prostacyclin (Prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH. Epoprostenol is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[1].
Name prostaglandin I2
Synonyms PGX
Epoprostenol
MFCD00135629
Prostaglandin l2
prostacyclin
Vasocyclin
PGl2
ProstaglandinI
PGX(prostaglandin)
Cyclo-Prostin
EINECS 263-273-7
Prostaglandin X
Description Epoprostenol (Prostaglandin I2), the synthetic form of the natural prostaglandin derivative Prostacyclin (Prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH. Epoprostenol is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[1].
Related Catalog
Target

Human Endogenous Metabolite
References

[1]. Provencher S, et al.Quality of life, safety and efficacy profile of thermostable flolan in pulmonary arterialhypertension. PLoS One. 2015 Mar 20;10(3):e0120657.
Density 1.221g/cm3
Boiling Point 530.2ºC at 760mmHg
Molecular Formula C20H31NaO5
Molecular Weight 374.44700
Flash Point 182.1ºC
Exact Mass 374.20700
PSA 89.82000
LogP 2.07380
Index of Refraction 1.611

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8008500
CHEMICAL NAME :
Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-
CAS REGISTRY NUMBER :
35121-78-9
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H32-O5
MOLECULAR WEIGHT :
352.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 mg/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 33,193,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
800 ng/kg
SEX/DURATION :
female 1-4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Maternal Effects - other effects
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 94,279,1992
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S22;S26;S36

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title: CAS No. 35121-78-9 | Chemsrc address: https://www.chemsrc.com/en/baike/330317.html

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