Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Atipamezole hydrochloride
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Atipamezole HCl
Price: $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Atipamezole hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Atipamezole hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Atipamezole hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Contact: Anson

104075-48-1

104075-48-1 structure

104075-48-1 structure

Name: Atipamezole hydrochloride
Chemical Name: Atipamezole hydrochloride
CAS Number: 104075-48-1
Molecular Formula: C₁₄H₁₇ClN₂
Molecular Weight: 248.751
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-08-15 21:33:04
Modify Date: 2024-01-02 11:01:06
Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.

Name	Atipamezole hydrochloride
Synonyms	5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride 1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, hydrochloride (1:1) Atipamezole hydrochloride 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride (1:1) 1H-Imidazole,4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-,monohydrochloride 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride 4-(2-Ethyl-2-indanyl)imidazole hydrochloride Atipamezole HCL 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazolehydrochloride Atipamezole (hydrochloride)

Description	Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	Ki: 1.6 nM[1]
In Vitro	The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].
In Vivo	Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1].
References	[1]. Pertovaara A, et al.Pharmacological properties, central nervous system effects, and potential therapeutic applicationsof atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev. 2005 Autumn;11(3):273-88.

Density	1.115g/cm3
Boiling Point	367.1ºC at 760mmHg
Molecular Formula	C₁₄H₁₇ClN₂
Molecular Weight	248.751
Flash Point	178ºC
Exact Mass	248.108032
PSA	28.68000
LogP	3.65830
Vapour Pressure	1.17E-06mmHg at 25°C
Storage condition	Desiccate at RT

HS Code	2933290090

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%