Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Benzyloxyphenol
Price: ￥200.0/20mg ￥150.0/25g ￥440.0/100g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Monobenzone (Benoquin)
Price: $275.0/100mg $500.0/250mg $1100.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Benzyloxyphenol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: PBP
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Monobenzone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

103-16-2

103-16-2 structure

Name: 4-Benzyloxyphenol
Chemical Name: monobenzone
CAS Number: 103-16-2
Molecular Formula: C₁₃H₁₂O₂
Molecular Weight: 200.233
Catalog: Chemical reagent Organic reagent Phenols
Create Date: 2018-08-17 00:15:27
Modify Date: 2024-01-02 21:58:14
Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research[1].

Name	monobenzone
Synonyms	4-Benzyloxyphenol 4-(Benzyloxy)phenol agerite Phenol, p- (benzyloxy)- Hydroquinone Monobenzyl Ether EINECS 203-083-3 4-benzyloxy phenol Phenol, 4-(phenylmethoxy)- Phenol, 4- (phenylmethoxy)- 4-(Benzyloxy)benzolol 4-(Benzyloxyl)phenol Benzyl hydroquinone MFCD00002333 PBP

Description	Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Zhu Y, et al. A mouse model of vitiligo induced by monobenzone. Exp Dermatol. 2013 Jul;22(7):499-501. doi: 10.1111/exd.12184.

Density	1.2±0.1 g/cm3
Boiling Point	359.1±17.0 °C at 760 mmHg
Melting Point	119-120 °C(lit.)
Molecular Formula	C₁₃H₁₂O₂
Molecular Weight	200.233
Flash Point	213.4±5.9 °C
Exact Mass	200.083725
PSA	29.46000
LogP	2.96
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.603
Water Solubility	slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ7700000

CHEMICAL NAME :: Phenol, p-(benzyloxy)-

CAS REGISTRY NUMBER :: 103-16-2

BEILSTEIN REFERENCE NO. :: 1958305

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C13-H12-O2

MOLECULAR WEIGHT :: 200.25

WISWESSER LINE NOTATION :: QR DO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,357,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,983,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 163 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4903 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 367 (estimated) No. of Female Employees: 16 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317-H319
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36;R43
Safety Phrases	S24/25-S26-S37
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	SJ7700000
Packaging Group	I; II; III
HS Code	29095090

Precursor 8
200956-20-3 100-39-0 123-31-9 106-51-4
100-51-6 146631-00-7 50635-26-2 6311-66-6
DownStream 10
108154-93-4 3780-50-5 3351-59-5 3233-32-7
38559-92-1 143389-15-5 142717-44-0 142627-91-6
18110-26-4 2150-58-5

HS Code	2909500000
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

103-16-2	79352-66-2
96315-18-3	194981-61-8
40232-88-0	144153-83-3
32418-97-6	51771-17-6
82212-14-4	91335-13-6