57248-88-1

57248-88-1 structure

Name: Pamidronate disodium
Chemical Name: Disodium Pamidronate Hydrate
CAS Number: 57248-88-1
Molecular Formula: C₃H₁₁NNa₂O₇P₂
Molecular Weight: 281.05
Catalog: API Water, electrolyte and acid-base balance regulator Electrolyte balance regulator
Create Date: 2018-02-24 08:00:00
Modify Date: 2024-01-02 18:32:27
Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.Target: OthersPamidronate belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) by people who have cancer. Pamidronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours and multiple myeloma (cancer of the bone marrow). Pamidronate is also used to treat the symptoms of Paget's disease of bone.

Name	Disodium Pamidronate Hydrate
Synonyms	Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)] Pamidronate disodium salt Pamidronate disodium Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2) Dinatrium-(3-amino-1-hydroxypropan-1,1-diyl)bis[hydrogen-(phosphonat)] APD Disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate MFCD01938386 EINECS 260-647-1 (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium Pamidronate (Disodium)

Description	Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.Target: OthersPamidronate belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) by people who have cancer. Pamidronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours and multiple myeloma (cancer of the bone marrow). Pamidronate is also used to treat the symptoms of Paget's disease of bone.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Zarychanski, R., et al., Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol, 2006. 81(1): p. 73-5.

CHEMICAL NAME :: Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - diplopia Sense Organs and Special Senses (Eye) - effect, not otherwise specified

REFERENCE :: ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 24,320,1994

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,622,1987

REFERENCE :: APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 31,499,1997 ** REPRODUCTIVE DATA **

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992

Hazard Codes	Xn
Risk Phrases	R22:Harmful if swallowed. R48:Danger of serious damage to health by prolonged exposure. R41:Risk of serious damage to eyes. R37/38:Irritating to respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Phrases	S22:Do not breathe dust . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek m
WGK Germany	3
RTECS	SZ6525000
HS Code	2931900090

HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%