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5949-11-1

5949-11-1 structure
5949-11-1 structure
  • Name: Cinchonine hydrochloride
  • Chemical Name: Cinchonine monohydrochloride hydrate
  • CAS Number: 5949-11-1
  • Molecular Formula: C19H23ClN2O
  • Molecular Weight: 330.852
  • Catalog: API Antiparasitic drug Antimalarial
  • Create Date: 2018-03-20 08:00:00
  • Modify Date: 2025-08-19 20:51:41
  • Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural compound present in Cinchona bark. Cinchonine hydrochloride activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].
Name Cinchonine monohydrochloride hydrate
Synonyms Cinchonan-9-ol, (9S)-, hydrochloride (1:1)
Cinchonan-9-ol, hydrochloride, (9S)-
Hydrogen chloride (9S)-cinchonan-9-ol (1:1:1)
cinchonan-9-ol,monohydrochloride, (9s)-
cinchonine hydrochloride hydrate
cinchonine hydrochloride dihydrate
cinchonine hydrochloride
cinchodinine dihydrochloride
cinchonine monohydrochloride dihydrate
cinchonine hydrochloride, hydrate
Cinchonan-9-ol, chloride, hydrogen salt, (9S)- (1:1)
l-cinchonine hydrochloride
Description Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural compound present in Cinchona bark. Cinchonine hydrochloride activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].
Related Catalog
References

[1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050.
Boiling Point 464.5ºC at 760 mmHg
Melting Point 208-218ºC(lit.)
Molecular Formula C19H23ClN2O
Molecular Weight 330.852
Exact Mass 330.149902
PSA 36.36000
LogP 3.90450

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD2962020
CHEMICAL NAME :
Cinchonan-9-ol, monohydrochloride, (9S)-
CAS REGISTRY NUMBER :
5949-11-1
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C19-H22-N2-O.Cl-H
MOLECULAR WEIGHT :
330.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2550093
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992
Hazard Codes Xi,Xn
Risk Phrases R20/21/22
Safety Phrases 36/37-26
RIDADR UN 1544
WGK Germany 3
RTECS GD2962020
Packaging Group III
Hazard Class 6.1(b)
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