1415692-17-9

1415692-17-9 structure

Name: 4-(4-((4-Chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoicacidcompoundwithbenzenesulfonicacid(1:1)
Chemical Name: bepotastine besilate
CAS Number: 1415692-17-9
Molecular Formula: C₂₇H₃₁ClN₂O₆S
Molecular Weight: 547.06
Catalog: Research Areas Endocrinology
Create Date: 2018-06-20 18:31:32
Modify Date: 2024-01-12 11:06:52
(Rac)-Bepotastine (besilate) is the inactive isomer of Bepotastine (besilate) (HY-A0015), and can be used as an experimental control. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research[1][2][3][4].

Name	bepotastine besilate

Description	(Rac)-Bepotastine (besilate) is the inactive isomer of Bepotastine (besilate) (HY-A0015), and can be used as an experimental control. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research[1][2][3][4].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Kida T, et al. Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91(1):85-91. [2]. Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811(18)30186-5. [3]. Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145(4):277-82. [4]. Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26(10):2329-38.

Precursor 0
DownStream 1
125602-71-3