66176-93-0

66176-93-0 structure

Name: cimicifugoside
Chemical Name: cimicifugoside
CAS Number: 66176-93-0
Molecular Formula: C₃₇H₅₄O₁₁
Molecular Weight: 674.81800
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-04-03 08:00:00
Modify Date: 2025-08-25 21:46:02
Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2].

Name	cimicifugoside
Synonyms	Prim-O-glucosylcimifygin

Description	Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	Nucleoside transport[1]
References	[1]. Yawata A, et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. Eur J Pharm Sci. 2009 Nov 5;38(4):355-61. [2]. Hemmi H, et al. The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. J Pharmacobiodyn. 1980 Dec;3(12):643-8.