512-06-1

512-06-1 structure

Name: yamogenin
Chemical Name: Yamogenin
CAS Number: 512-06-1
Molecular Formula: C₂₇H₄₂O₃
Molecular Weight: 414.621
Catalog: Biochemical Plant extracts
Create Date: 2018-08-28 13:10:09
Modify Date: 2024-01-03 10:28:57
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes[1].

Name	Yamogenin
Synonyms	Spirost-5-en-3-ol, (3β,25S)- (3β,25S)-Spirost-5-en-3-ol yamogenin

Description	Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Metabolic Disease
Target	IC50: TG accumulation; liver X receptor (LXR)[1]
References	[1]. Moriwaki S, et al. Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.Biosci Biotechnol Biochem. 2014;78(7):1231-6.

91327-42-3

87-72-9

2280-44-6

10257-28-0

Detail

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 4 p. 1365 - 1372

7647-01-0

64-17-5

125710-71-6

512-06-1

Literature: Journal of the American Chemical Society, , vol. 77, p. 5661 Journal of the American Chemical Society, , vol. 80, p. 1984