Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 28-deoxonimbolide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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126005-94-5

126005-94-5 structure

Name: 28-Deoxonimbolide
Chemical Name: 28-deoxonimbolide
CAS Number: 126005-94-5
Molecular Formula: C₂₇H₃₂O₆
Molecular Weight: 452.539
Catalog: Natural product Moss
Create Date: 2017-10-28 22:01:26
Modify Date: 2025-08-21 11:18:51
28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways[1].

Name	28-deoxonimbolide
Synonyms	28-Deoxonimbolide Methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cS)-8-(3-furyl)-2a,5a,6a,7-tetramethyl-5-oxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate 2H,5H-Cyclopenta[d]naphtho[2,3-b:1,8-b'c']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-5-oxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cS)-

Description	28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase
Target	Caspase-8 Caspase-9 Caspase-3
In Vitro	28-Deoxonimbolide (1-100 μM，48 小时) 对 HL60 (白血病)、A549 (肺)、AZ521 (胃)、SK-BR-3 (乳腺)、CRL1579 (黑色素瘤)和 RPMI1788 (正常淋巴细胞) 显示强有力的细胞毒性[1]。 28-Deoxonimbolide (30 μM, 0-24 h) 诱导 HL60 细胞凋亡[1]。 28-Deoxonimbolide (30 μM, 0-24 h) 可增加裂解的 caspases-8、-9 和 -3 的水平[1]。 Cell Cytotoxicity Assay[1] Cell Line: HL60, A549, AZ521, SK-BR-3, CRL1579 cells, RPMI1788 Concentration: 1-100 μM Incubation Time: 48 h Result: Exhibited potent cytotoxic activity against HL60 (leukemia), A549 (lung), AZ521 (stomach), SK-BR-3 (breast), and CRL1579 (melanoma) cells, with IC50 values of 2.7 μM, 9.3 μM, 2.4 μM, 1.7 μM, 14.2 μM, and 2.7 μM, respectively. Apoptosis Analysis[1] Cell Line: HL60 cells Concentration: 30 μM Incubation Time: 8 and 24 h Result: Induced early apoptosis in HL60 cells. The ratio of early apoptotic cells was increased after 8 h (10.9% vs 6.1% of negative control) and 24 h (18.7% vs 3.5% of negative control), and that of late apoptotic cells (upper right) was increased after 24 h (28.1% vs 2.9% of negative control). Western Blot Analysis[1] Cell Line: HL60 cells Concentration: 30 μM Incubation Time: 8 and 24 h Result: Diminished the levels of procaspases-8, -9, and -3, and then increased the levels of cleaved caspases-8, -9, and -3.
References	[1]. Kikuchi T, et al. Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem). J Nat Prod. 2011 Apr 25;74(4):866-70.

Density	1.3±0.1 g/cm3
Boiling Point	554.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₂O₆
Molecular Weight	452.539
Flash Point	289.0±30.1 °C
Exact Mass	452.219879
PSA	74.97000
LogP	3.64
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.589

Hazard Codes	Xi

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