146389-61-9

146389-61-9 structure

Name: Zaragozic acid B
Chemical Name: 4,7-dihydroxy-1-[(E)-4-hydroxy-3,5-dimethyl-8-phenyloct-7-enyl]-6-[(6E,12E)-tetradeca-6,12-dienoyl]oxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
CAS Number: 146389-61-9
Molecular Formula: C₃₉H₅₄O₁₃
Molecular Weight: 730.83800
Catalog: Signaling Pathways Metabolic Enzyme/Protease Farnesyl Transferase
Create Date: 2017-05-25 20:29:04
Modify Date: 2024-01-10 19:23:10
Zaragozic acid B, a fungal metabolite, is a potent inhibitor of both farnesyl-protein transferase (FPTase) and squalene synthases. Zaragozic acid B is a potential anticancer drug[1].

Name	4,7-dihydroxy-1-[(E)-4-hydroxy-3,5-dimethyl-8-phenyloct-7-enyl]-6-[(6E,12E)-tetradeca-6,12-dienoyl]oxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
Synonyms	Zaragozic acid B

Description	Zaragozic acid B, a fungal metabolite, is a potent inhibitor of both farnesyl-protein transferase (FPTase) and squalene synthases. Zaragozic acid B is a potential anticancer drug[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase
In Vitro	Zaragozic acid B is a very potent inhibitor of squalene synthases from all three sources (RSS: rat liver microsome; YSS: Candida albicans; HSS: Hep G2 cells) with the IC50 values range from 0.22 to 0.67 nM[1]. Zaragozic acid B inhibits bovine FPTase (IC50=100 nM), human FPTase (IC50=185 nM)[1].
References	[1]. Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany • December 1995.