146204-42-4

146204-42-4 structure

Name: BM212
Chemical Name: 1-[[1,5-bis(4-chlorophenyl)-2-methylpyrrol-3-yl]methyl]-4-methylpiperazine
CAS Number: 146204-42-4
Molecular Formula: C₂₃H₂₅Cl₂N₃
Molecular Weight: 414.371
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-04-12 08:40:28
Modify Date: 2025-08-25 19:05:16
BM212 exerts bactericidal activity against intracellular bacilli residing, completely inhibits the intracellular mycobacteria.In vitro: BM212 is inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.[1] BM212 completely inhibits the intracellular mycobacteria.BM212 had inhibitory activity against all strains tested, with MICs between 0.7 and 1.5 μg/ml.[2]

Name	1-[[1,5-bis(4-chlorophenyl)-2-methylpyrrol-3-yl]methyl]-4-methylpiperazine
Synonyms	unii-u9hsu4gzwl 1-{[1,5-Bis(4-chlorophenyl)-2-methylpyrrol-3-yl]methyl}-4-methylpiperazine 1-{[1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine Piperazine, 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl- bm212

Description	BM212 exerts bactericidal activity against intracellular bacilli residing, completely inhibits the intracellular mycobacteria.In vitro: BM212 is inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.[1] BM212 completely inhibits the intracellular mycobacteria.BM212 had inhibitory activity against all strains tested, with MICs between 0.7 and 1.5 μg/ml.[2]
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) [2]. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. [3]. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains.