Top Suppliers:I want be here
Related CAS#:
55986-43-1 64059-66-1
1040642-98-5 1040643-14-8
1040643-22-8 1040643-30-8
1040643-38-6 1040643-46-6
1040643-54-6 1040643-70-6
1040643-78-4 1019489-24-7

55986-43-1

55986-43-1 structure
55986-43-1 structure
  • Name: Cetaben
  • Chemical Name: 4-(hexadecylamino)benzoic acid
  • CAS Number: 55986-43-1
  • Molecular Formula: C23H39NO2
  • Molecular Weight: 361.561
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2018-07-25 11:05:36
  • Modify Date: 2025-08-24 23:05:37
  • Cetaben, an exceptional type of peroxisome proliferator, is a peroxisome proliferator-activated receptor α (PPARα)-independent peroxisome proliferator. Cetaben is a non-fibrate hypolipidemic drug and potently reduces the concentration of cholesterol and triglycerides[1][2].
Name 4-(hexadecylamino)benzoic acid
Synonyms 4-(Hexadecylamino)benzoic acid
Peroxisome Proliferator,Cetaben
Benzoic acid, 4-(hexadecylamino)-
Cetaben
Description Cetaben, an exceptional type of peroxisome proliferator, is a peroxisome proliferator-activated receptor α (PPARα)-independent peroxisome proliferator. Cetaben is a non-fibrate hypolipidemic drug and potently reduces the concentration of cholesterol and triglycerides[1][2].
Related Catalog
In Vitro Cetaben (10 µM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 µM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles[2]. Cetaben-treated (10 µM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells[2].
In Vivo Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg[1]. Animal Model: Male Wistar rats[1] Dosage: 10,25,50,100,250 and 500 mg/kg Administration: Gavage; 10 day Result: Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg.
References

[1]. Chandoga J, et al. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Biochem Pharmacol. 1994 Feb 9;47(3):515-9.

[2]. Kovacs W, et al. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatomacells and HepG2 human hepatoblastoma cells. Histochem Cell Biol. 2001 Jun;115(6):509-19.
Density 1.0±0.1 g/cm3
Boiling Point 503.4±33.0 °C at 760 mmHg
Molecular Formula C23H39NO2
Molecular Weight 361.561
Flash Point 258.3±25.4 °C
Exact Mass 361.298065
PSA 49.33000
LogP 9.68
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.521
Storage condition -20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DH1430100
CHEMICAL NAME :
Benzoic acid, 4-(hexadecylamino)-
CAS REGISTRY NUMBER :
55986-43-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H39-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
19500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 7,273,1981
HS Code 2922499990
HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:55986-43-1 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 55986-43-1 | Chemsrc address: https://www.chemsrc.com/en/baike/27235.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved