DC Chemicals Limited
China
Product Name: Carteolol
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Purity: 98.0%
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51781-06-7

51781-06-7 structure

51781-06-7 structure

Name: Carteolol
Chemical Name: carteolol
CAS Number: 51781-06-7
Molecular Formula: C₁₆H₂₄N₂O₃
Molecular Weight: 292.37300
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-09-27 15:23:48
Modify Date: 2024-01-03 12:48:01
Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research[1].

Name	carteolol
Synonyms	Carteololum Carteolol [INN:BAN] Carteololum [INN-Latin] 5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one CARTEOLOL Ocupress Carteolol HCl Carteolol Monohydrochloride Carteolol (INN) 5-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-1H-quinolin-2-one 5-[3-(1,1-dimethylethyl)amino-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone

Description	Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
In Vitro	Carteolol (0-2%; 0-28 hours; HCECs) has cytotoxicity and decreases cell viability in a dose- and time-dependent manner[1]. Carteolol (0.25%; 4-12 hours; HCECs) induces apoptosis and necroptotic protein expression in HCECs[1]. Cell Viability Assay[1] Cell Line: HCECs Concentration: 0.00390625-2% Incubation Time: 0, 2, 4, 8, 16, 20,24 and 28 hours Result: Decreased cell viability with the concentrations above 0.0015625% in a dose- and time-dependent manner. Western Blot Analysis[1] Cell Line: HCECs Concentration: 0.25% Incubation Time: 4, 8 and 12 hours Result: Dampened expression of the anti-apoptotic protein Bcl-2 and Bcl-xL, enhanced expression of the pro-apoptotic proteins Bax and Bad, and mitochondrial-released pro-apoptotic proteins Cyt.c and AIF. Cell Cycle Analysis[1] Cell Line: HCECs Concentration: 0.25% Incubation Time: 4, 8 and 12 hours Result: Increased the number of G1 phase of the cell cycle, whereas decreased S phase.
References	[1]. Su W, et, al. Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms. Front Pharmacol. 2020 Mar 6;11:202.

Density	1.13 g/cm3
Boiling Point	518.6ºC at 760 mmHg
Molecular Formula	C₁₆H₂₄N₂O₃
Molecular Weight	292.37300
Flash Point	267.4ºC
Exact Mass	292.17900
PSA	70.59000
LogP	2.22800
Index of Refraction	1.5800 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC8281000

CHEMICAL NAME :: 2(1H)-Quinolinone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4 -dihydro-

CAS REGISTRY NUMBER :: 51781-06-7

LAST UPDATED :: 199112

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H24-N2-O3

MOLECULAR WEIGHT :: 292.42

WISWESSER LINE NOTATION :: T66 BMVT&J GO1YQ1MX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 810 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,121,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980

HS Code	2933790090

51781-21-6 structure

51781-21-6

~95%

51781-06-7 structure

51781-06-7

Literature: Spataro, Gregory; Malecaze, Francois; Turrin, Cedric-Olivier; Soler, Vincent; Duhayon, Carine; Elena, Pierre-Paul; Majoral, Jean-Pierre; Caminade, Anne-Marie European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 326 - 334

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%