92933-48-7
92933-48-7 structure
- Name: LUF 6283
- Chemical Name: 5-Butyl-1H-pyrazole-3-carboxylic acid
- CAS Number: 92933-48-7
- Molecular Formula: C8H12N2O2
- Molecular Weight: 168.19300
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PERK
- Create Date: 2016-01-06 03:16:02
- Modify Date: 2024-01-04 08:09:45
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LUF6283 is a potent and orally active HCA(2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect[1].
| Name | 5-Butyl-1H-pyrazole-3-carboxylic acid |
|---|---|
| Synonyms |
5-butyl-[1,3,5]triazinane-2-thione
Dihydrokainic acid 5-Butyl-1(2)H-pyrazol-3-carbonsaeure 5-Butyl-tetrahydro-s-triazin-2(1H)-thion 5-butyl-1,4,5,6-tetrahydro-1,3,5-triazine-2-thiol 1-Butyl-hexahydrotriazinthion-4 5-butyl-1(2)H-pyrazole-3-carboxylic acid |
| Description | LUF6283 is a potent and orally active HCA(2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 0.32 ± 0.06 μM (pERK1/2)[1] |
| In Vivo | LUF6283 (C57BL/6 mice, 400 mg/kg, Oral gavage, once a day for 4 weeks) has no effect on adipose tissue ATGL/HSL expression, and significantly reduces the expression of apolipoprotein B (APOB)[1]. |
| References |
| Molecular Formula | C8H12N2O2 |
|---|---|
| Molecular Weight | 168.19300 |
| Exact Mass | 168.09000 |
| PSA | 65.98000 |
| LogP | 1.45050 |
| RIDADR | NONH for all modes of transport |
|---|
|
~69%
92933-48-7 |
| Literature: Seki; Isegawa; Fukuda; Ohki Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1568 - 1577 |
|
~%
92933-48-7 |
| Literature: Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951 |
|
~%
92933-48-7 |
| Literature: Lehninger Journal of Biological Chemistry, 1944 , vol. 153, p. 564 |
|
~%
92933-48-7 |
| Literature: Lehninger Journal of Biological Chemistry, 1944 , vol. 153, p. 564 |
