1531634-31-7

1531634-31-7 structure

Name: AF38469
Chemical Name: af38469
CAS Number: 1531634-31-7
Molecular Formula: C₁₅H₁₁F₃N₂O₃
Molecular Weight: 324.25500
Catalog: Research Areas Others
Create Date: 2016-01-24 13:43:56
Modify Date: 2024-01-21 20:28:35
AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.

Name	af38469
Synonyms	2-[(6-methylpyridin-2-yl)carbamoyl]-5-(trifluoromethyl)benzoic acid

Description	AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
Target	IC50:330 nM (Sortilin)[1]
In Vitro	AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate evaluation of the therapeutic potential of this protein[1].
References	[1]. Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80.