14133-90-5

14133-90-5 structure

Name: 4-hydroxy propranolol hcl
Chemical Name: rac-4-Hydroxy Propranolol Hydrochloride
CAS Number: 14133-90-5
Molecular Formula: C₁₆H₂₂ClNO₃
Molecular Weight: 311.804
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-07-07 08:39:30
Modify Date: 2024-01-02 20:00:59
4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].

Name	rac-4-Hydroxy Propranolol Hydrochloride
Synonyms	2-Propanol, 1-((4-hydroxy-1-naphthyl)oxy)-3-(isopropylamino)-, hydrochloride 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)-1-naphthalenol hydrochloride 1-Naphthalenol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, hydrochloride (1:1) 4-hydroxy propranolol hcl 1-Naphthalenol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, hydrochloride 4-[2-Hydroxy-3-(isopropylamino)propoxy]-1-naphthol hydrochloride (1:1)

Description	4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	pA2: 8.24 (β1-adrenergic receptor) and 8.26 (β2-adrenergic receptor)[2]
References	[1]. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35. [2]. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61. [3]. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90.

RIDADR	NONH for all modes of transport
HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%