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24237-54-5

24237-54-5 structure
24237-54-5 structure
  • Name: Tinoridine
  • Chemical Name: ethyl 2-amino-6-benzyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
  • CAS Number: 24237-54-5
  • Molecular Formula: C17H20N2O2S
  • Molecular Weight: 316.41800
  • Catalog: API Antipyretic analgesics Non-steroidal anti-inflammatory drugs
  • Create Date: 2018-12-25 17:11:18
  • Modify Date: 2024-01-02 15:50:31
  • Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. [1][2][3].

Name ethyl 2-amino-6-benzyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
Synonyms Dimaten
Tinoridine
Y 3642
2-Amino-6-benzyl-4,5,6,7-tetrahydro-thieno<pyridin-3-carbonsaeuereethylester
Description Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. [1][2][3].
Related Catalog
In Vitro Tinoridine (10-100 μM) exerts effect on stability of rat liver and kidney lysosomes, and liver parenchymal cells[3]. Tinoridine (1, 10, and 100 μM; 30 min) inhibits spontaneous release of acid phosphatase from liver lymomoses in vitro[3].
In Vivo Tinoridine (100 mg/kg; p.o.; single dose) inhibits CCl4 hepatotoxicity in rats, with a strong control of the CCl4-induced enzyme activities[2]. Tinoridine (100 mg/kg; i.p.; single dose) protects the stability of rat liver and kidney lysosomes in vivo[3]. Animal Model: Male Wistar rats (180-220 g)[2] Dosage: 100 mg/kg Administration: Oral gavage; single dose; 1 hour before CCl4 (i.p.; 0.25 mL/kg) treatment Result: Inhibited the CCl4-induced enzyme activities increase of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and also rescued the liver microsomal cytochrome P-450 and glucose-6-phosphatase activities.
Density 1.256 g/cm3
Boiling Point 493.5ºC at 760 mmHg
Melting Point 112-113ºC
Molecular Formula C17H20N2O2S
Molecular Weight 316.41800
Exact Mass 316.12500
PSA 83.80000
LogP 3.58440
Vapour Pressure 7E-10mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ9088300
CHEMICAL NAME :
Thieno(2,3-c)pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-2-amino-6-benzyl-, ethyl ester
CAS REGISTRY NUMBER :
24237-54-5
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H20-N2-O2-S
MOLECULAR WEIGHT :
316.45
WISWESSER LINE NOTATION :
T56 BS HN&TJ CZ DVO2 H1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,998,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,998,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,998,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,998,1970
HS Code 2934999090
Precursor  2

DownStream  0

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%