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975-77-9

975-77-9 structure

975-77-9 structure

Name: Pericyclivine
Chemical Name: (+)-Pericyclivine
CAS Number: 975-77-9
Molecular Formula: C₂₀H₂₂N₂O₂
Molecular Weight: 322.401
Catalog: Natural product Alkaloid
Create Date: 2018-03-15 08:00:00
Modify Date: 2024-01-02 14:35:34
Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2].

Name	(+)-Pericyclivine
Synonyms	pericyclivine Pericyclivin Desformoakuammidin Sarpagan-17-oic acid, methyl ester, (15α)- Methyl (15α,19E)-sarpagan-17-oate sarpagan-17-oic acid methyl ester Deformoakuammidine

Description	Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Pericyclivine shows cytotoxicity against the P-388 cell culture system with an ED50 of 13 μg/mL[2].
References	[1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9. [2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51.

Density	1.3±0.1 g/cm3
Boiling Point	489.2±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₂N₂O₂
Molecular Weight	322.401
Flash Point	249.7±28.7 °C
Exact Mass	322.168121
PSA	45.33000
LogP	3.50
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.673

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VQ5835000

CHEMICAL NAME :: Sarpagan-17-oic acid, methyl ester, (16S)-

CAS REGISTRY NUMBER :: 975-77-9

LAST UPDATED :: 197905

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H20-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04199

Hazard Codes	Xi