165668-41-7

165668-41-7 structure

Name: Indisulam
Chemical Name: 4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
CAS Number: 165668-41-7
Molecular Formula: C₁₄H₁₂ClN₃O₄S₂
Molecular Weight: 385.846
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2018-12-20 20:18:29
Modify Date: 2024-01-11 13:13:24
Indisulam (E 7070) is a carbonic anhydrase inhibitor and a G1-targeting agent. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 (CDK2) and cyclin E. Shows anti-tumor activity in human colon and lung cancer cells[1][2].

Name	4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
Synonyms	E7070 Indisulam (IND) 1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)- indisulam N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide N-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide Indisulam (USAN/INN) 1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl)

Description	Indisulam (E 7070) is a carbonic anhydrase inhibitor and a G1-targeting agent. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 (CDK2) and cyclin E. Shows anti-tumor activity in human colon and lung cancer cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Target	Carbonic anhydrase[1].
References	[1]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82. [2]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%