138090-06-9
138090-06-9 structure
- Name: (R,R)-THC
- Chemical Name: cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
- CAS Number: 138090-06-9
- Molecular Formula: C22H24O2
- Molecular Weight: 320.42
- Catalog: Research Areas Metabolic Disease
- Create Date: 2017-02-17 10:48:01
- Modify Date: 2024-01-05 18:46:12
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(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].
| Name | cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol |
|---|---|
| Synonyms | (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol |
| Description | (R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1]. |
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| Related Catalog | |
| Target |
ERα:9.0 nM (Ki) ERβ:3.6 nM (Ki) |
| References |
| Density | 1.21g/cm3 |
|---|---|
| Boiling Point | 519ºC at 760mmHg |
| Molecular Formula | C22H24O2 |
| Molecular Weight | 320.42 |
| Flash Point | 239.5ºC |
| Exact Mass | 320.17800 |
| PSA | 40.46000 |
| LogP | 5.17320 |
| Vapour Pressure | 2.17E-11mmHg at 25°C |
| Index of Refraction | 1.65 |
| Safety Phrases | S22 |
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~%
138090-06-9 |
| Literature: Hwang, Kwang-Jin; O'Neil, James P.; Katzenellenbogen, John A. Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1262 - 1271 |
| Precursor 1 | |
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| DownStream 0 | |