86484-91-5
86484-91-5 structure
- Name: Dopexamine hydrochloride
- Chemical Name: Dopexamine Hydrochloride
- CAS Number: 86484-91-5
- Molecular Formula: C22H34Cl2N2O2
- Molecular Weight: 429.42400
- Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
- Create Date: 2018-03-14 08:00:00
- Modify Date: 2024-01-11 17:13:23
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Dopexamine hydrochloride is a β2 adrenergic receptor agonist.
| Name | Dopexamine Hydrochloride |
|---|---|
| Synonyms | 4-[2-[6-(2-phenylethylamino)hexylamino]ethyl]benzene-1,2-diol,dihydrochloride |
| Description | Dopexamine hydrochloride is a β2 adrenergic receptor agonist. |
|---|---|
| Related Catalog | |
| Target |
β2 adrenergic receptor[1] |
| In Vitro | Dopexamine is a dopamine analogue with agonist activity at β2 and dopaminergic receptors. Dopexamine can attenuate the systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow[1]. Dopexamine is a dopamine analog that stimulates β-adrenergic and dopamine 1 and 2 receptors, conferring some vasodilatory effects. Dopexamine reduces the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without substantially changing systemic hemodynamics, either blood pressure or stroke volume[2]. |
| References |
[2]. Hollenberg SM. Dopexamine: immunomodulatory, hemodynamic, or both? Crit Care. 2013 May 13;17(3):143. |
| Boiling Point | 546.7ºC at 760 mmHg |
|---|---|
| Molecular Formula | C22H34Cl2N2O2 |
| Molecular Weight | 429.42400 |
| Flash Point | 115.1ºC |
| Exact Mass | 428.20000 |
| PSA | 64.52000 |
| LogP | 6.00840 |
| Storage condition | 2-8°C |
| Water Solubility | Soluble in water, sparingly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone. |