108319-06-8

108319-06-8 structure

Name: temafloxacin
Chemical Name: 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
CAS Number: 108319-06-8
Molecular Formula: C₂₁H₁₈F₃N₃O₃
Molecular Weight: 417.38100
Catalog: API Synthetic anti-infective drugs Quinolone
Create Date: 2018-07-27 18:46:34
Modify Date: 2024-01-09 12:45:01
Temafloxacin (TMFX) is a quinolone antimicrobial agent that has a broad antibacterial spectrum against Gram-positive, Gram-negative and anaerobic bacteria[1][2].

Name	1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Synonyms	[14C]-Temafloxacin Temafloxacina [Spanish] 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid Temafloxacina 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)-quinoline-3-carboxylic acid Omniflox Temafloxacinum [Latin] Temafloxacine 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid Temafloxacinum Temafloxacine [French] Temafloxacin

Description	Temafloxacin (TMFX) is a quinolone antimicrobial agent that has a broad antibacterial spectrum against Gram-positive, Gram-negative and anaerobic bacteria[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Temafloxacin has broad antimicrobial activity against gram-positive and gram-negative bacteria, including improved in vitro activity against Streptococcus pneumoniae, Mycoplasma hominis, and anaerobic bacteria, including Bacteroides fragilis[2].
In Vivo	Temafloxacin is a fluoroquinolone with a 7-8 hour half-life and rapid gastrointestinal absorption. With the exception of the central nervous system (CNS), Temafloxacin has excellent tissue and body fluid penetration and concentration[2].
References	[1]. S Matsuda, et al. Experimental and clinical studies of temafloxacin in the field of obstetrics and gynecology. Jpn J Antibiot. 1993 Jun;46(6):492-504. [2]. G A Pankey. Temafloxacin: an overview. Am J Med. 1991 Dec 30;91(6A):166S-172S.

CHEMICAL NAME :: 3-Quinolinecarboxylic acid, 1,4-dihydro-1-(2,4-difluorophenyl)-6-fluoro-7- (3-methyl-1-piperazinyl)-4-oxo-

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in sodium

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Musculoskeletal - joints Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 37,213,1993