139026-64-5

139026-64-5 structure

Name: [Lys8, Lys9]-Neurotensin (8-13)
Chemical Name: [Lys8,9]-Neurotensin (8-13),KKPYIL
CAS Number: 139026-64-5
Molecular Formula: C₃₈H₆₄N₈O₈
Molecular Weight: 760.96400
Catalog: Signaling Pathways GPCR/G Protein Neurotensin Receptor
Create Date: 2018-10-13 18:31:18
Modify Date: 2024-01-10 17:14:31
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].

Name	[Lys8,9]-Neurotensin (8-13),KKPYIL
Synonyms	[lys8,9]-neurotensin (8-13) lys-lys-pro-tyr-ile-leu h-lys-lys-pro-tyr-ile-leu-oh kkpyil (lys8,lys9)-neurotensin (8-13)

Description	[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease
References	[1]. Emilie Eiselt, et al. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chem Neurosci. 2019 Nov 20;10(11):4535-4544.