1420-36-6
1420-36-6 structure
- Name: S-Acetoacetylcoenzyme a
- Chemical Name: acetoacetyl-CoA
- CAS Number: 1420-36-6
- Molecular Formula: C25H40N7O18P3S
- Molecular Weight: 851.61
- Create Date: 2017-01-26 18:34:50
- Modify Date: 2025-08-22 06:42:10
-
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids[1][2][3].
| Name | acetoacetyl-CoA |
|---|---|
| Synonyms | S-Acetoacetylcoenzyme a |
| Description | Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | The purified recombinant Msed_0389 and Msed_1423 catalyze the NAD-dependent oxidation of (S)-3-hydroxybutyryl-CoA to Acetoacetyl-CoA and are highly specific for their substrate (Km of 2.6 μM and 5 μM, respectively)[2]. The homologous bifunctional protein is the only enzyme capable to covert crotonyl-CoA into Acetoacetyl-CoA in autotrophic Desulfurococcales (Ignicoccus hospitalis) and Thermoproteales (Pyrobaculum neutrophilus) that use the dicarboxylate/4-hydroxybutyrate cycle for CO2 fixation[2]. |
| References |
| Molecular Formula | C25H40N7O18P3S |
|---|---|
| Molecular Weight | 851.61 |
| Exact Mass | 851.13600 |
| PSA | 435.43000 |
| LogP | 0.00680 |
| Storage condition | 20°C |
